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MI-CP151 was a phase 1b randomised, double-blind, placebo managed, dose-escalation, multicentre study To guage various intravenous doses of sifalimumab, in adult patients with dermatomyositis or polymyositis (NCT00533091). Key demo objectives have been To judge the protection and tolerability of sifalimumab in dermatomyositis or polymyositis people

These results elevate some questions on the regulation of caspase activation. Why are two cleavage occasions necessary to remove the prodomain? Our facts exhibit the cleavage at D9 is required for cleavage at D28. A person attainable clarification is that recognition and binding on the D9 site orients the prodomain for cleavage at D28. This may sug